Wistar-Led Team Awarded More Than $12 Million Grant from the NCI to Investigate Link Between Epstein-Barr Virus and Carcinomas

PHILADELPHIA, PA, July 26, 2023 (GLOBE NEWSWIRE) — It’s been known since the 1960s that Epstein-Barr Virus (EBV) causes a variety of cancers, but research has overwhelmingly focused on its connection to lymphomas. Now, a multidisciplinary team of scientists led by The Wistar Institute has been awarded a more than $12 million National Cancer Institute (NCI) Program Project Grant (P01), a highly competitive five-year grant that includes a crosssection of researchers from various disciplines and institutions throughout the country. The multidisciplinary team led by Wistar scientists is exploring the role of Epstein-Barr Virus in epithelial cancers. Epithethelial cells form functional structures in organ tissue throughout the human body; they are often the site for solid organ cancers, including the most common cancers, which are known as carcinomas.

The new research will focus on basic questions about how EBV infection of normal epithelial cells transforms them into cancer-cells. Scientists also intend to build on this research to identify better and more selective therapeutic targets.

“We are investigating unexplored aspects of EBV and malignancies, potentially uncovering unique characteristics or pathways that can be targeted for therapeutic intervention,” said Italo Tempera, Ph.D., associate professor of the Gene Expression & Regulation Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute. “This fresh perspective could lead to groundbreaking discoveries and innovative treatment strategies for EBV and epithelial malignancies.”

The project brings together scientists from The Wistar Institute and Harvard University, including experts in epigenetics, metabolomics and drug discovery. It’s the first time researchers from this variety of disciplines have combined their efforts to focus entirely on the EBV-epithelial cancer link.

“We’ve put together a new strategy, a new way of attacking the problem,” said Paul Lieberman, Ph.D., Hilary Koprowski, M.D., Endowed Professor and director of the Center for Chemical Biology and Translational Medicine at Wistar. “By working together across different modalities, there’s an opportunity for each of us to learn from the synergy and expertise of the other investigators.”

EBV is one of the most common human viruses, infecting an estimated 95% of people by the time they reach adulthood. Symptoms are usually mild, and most people recover within a few weeks. However, the virus can remain latent in the human body for years or even decades, and it causes some people to develop cancer later in life.

While research has historically focused on lymphomas, EBV-linked epithelial cancers are both more common and more deadly. Epithelial cancers represent 75% of the 200,000 EBV-related cancer cases diagnosed each year, and these cancers also have higher mortality rates and treatment failures.

“This grant put together a team that is now focused on this type of cancer that has been neglected, even though it’s the most common form of EBV cancers,” Lieberman said. The grant will fund three main research projects. The first will look at how EBV establishes a long-term infection within epithelial cells. The second will study how it causes genetic and metabolic changes to trigger cancer growth. Finally, researchers will use these findings to investigate new therapeutic strategies.

The research builds on past work by Lieberman’s lab, which has focused on developing small molecule inhibitors targeting EBV. He said the new project would focus on studying drugs that are already in development, and looking for ways to make them more targeted or use them in combination with other therapies.

Tempera said the group’s integrated approach sets it apart.“Our project will study both metabolic and epigenetic vulnerabilities simultaneously,” he said. “Combining these two aspects can provide a comprehensive understanding of the role of EBV infection in cancer and its underlying mechanisms, leading to unique insights and therapeutic opportunities.”

Co-authors: Ben Gewurz of Harvard; Joseph Salvino, Samantha Soldan, Andrew Kossenkov, Louise Showe, and Qin Liu of Wistar.

Darien Sutton
The Wistar Institute
215-870-2048
[email protected]

GlobeNewswire Distribution ID 8881269

Hitachi Energy selected as preferred technology provider for the longest HVDC link in the UK

HVDC interconnection to secure power transmission and support new renewable electricity generation with the country’s largest electricity transmission project

Zurich, Switzerland, July 26, 2023 (GLOBE NEWSWIRE) — Hitachi Energy, a global technology leader that is advancing a sustainable energy future for all, today announced it has been selected as preferred technology provider of SSEN Transmission and National Grid, to supply two high-voltage direct current (HVDC) converter stations to interconnect the Scottish and English power grids.

The energy transition requires a collaborative effort that can only be achieved with advanced technologies and new ways of working. In appointing Hitachi Energy as their preferred technology provider, SSEN Transmission and National Grid secure best-in-class technology and future production capacity in a rapidly growing market. For Hitachi Energy, this enables investment in new production capacity and to undertake large-scale recruitment drives. It also strengthens collaboration, standardization of solutions, and synergies between projects.

The integration of renewables requires solutions that make the grid resilient, stable, and flexible. Hitachi Energy’s innovation and long development of voltage sourced converter (VSC) power electronics and control and protection (MACH™) technologies meet the requirements alongside many other landmark grid integration projects.

Eastern Green Link 2 will consist of two 525-kilovolt (kV) bipole VSC converter stations connected by 440 kilometers of subsea cable and 70 kilometers of underground cable, making it the longest HVDC link in the UK. The link will efficiently supply a total of 2,000 megawatts (MW) of electricity, which is enough to power around two million UK homes.1

The link will help to secure power transmission in the northern UK and support the integration of new renewable electricity generation in Scotland, as part of the UK’s Net Zero Strategy.2 As much as 11,000 MW of offshore wind capacity is possible in Scottish waters by 20303, and HVDC transmission will play a large part in bringing this vast amount of renewable power to shore and south, to communities across the country.

“The UK’s Net Zero Strategy has ambitious targets which will require vast amounts of new renewable generation. Electricity will be the backbone of the entire energy system,” said Niklas Persson, Managing Director at Hitachi Energy’s Grid Integration business. “Our pioneering HVDC technology will ensure that this electricity will reliably and efficiently get where it’s needed most.”

“This is another important milestone for EGL2 which is part of the new network infrastructure required to help the UK meet its net zero and energy security ambitions,” said Sarah Sale, Deputy Project Director of National Grid. “Along with cabling bidder and formal joint venture announcements, this is another key part of the project which is now in place and ready for the delivery phase. We look forward to working in collaboration with Hitachi Energy and BAM as the project continues to progress.”

“The converter stations at either end of the cable will play a crucial role in making the power transported subsea suitable for transportation around the onshore transmission network – getting Hitachi Energy and BAM in place to deliver that technology is great for the project,” said Ricky Saez, the EGL2 Project Director from SSEN Transmission.

“BAM is delighted to work in collaboration with Hitachi Energy on this vital renewable energy project for National Grid and SSEN Transmission,” said Huw Jones, Executive Director of BAM Nuttall. “The converter stations will enable the transmission of green energy from areas of offshore wind generation to centers of population, supporting the UK’s net zero ambitions and providing better energy security. We look forward to engaging with local communities and suppliers in Aberdeenshire and North Yorkshire, supporting BAM’s vision to deliver sustainable infrastructure for our clients, stakeholders, and the communities in which we work.”

Hitachi Energy is collaborating with BAM, a construction company that designs, builds, and maintains sustainable buildings and infrastructure, to provide the civil and installation scope for the project. The collaboration with BAM will leverage the core competencies of the two companies to deliver a best-in-class solution for the project.

Hitachi Energy pioneered commercial HVDC technology almost 70 years ago and has delivered more than half of the world’s HVDC projects.

1 https://www.nationalgrid.com/electricity-transmission/network-and-infrastructure/segl2
2 https://www.gov.uk/government/publications/net-zero-strategy
3 https://www.gov.scot/publications/offshore-wind-policy-statement/
4 Modular Advanced Control for HVDC (MACH™)

HVDC website:

https://www.hitachienergy.com/offering/product-and-system/hvdc

Photo captions:

North Sea Link Blyth Converter Station UK

Eastern Green Link 2

About Hitachi Energy
Hitachi Energy is a global technology leader that is advancing a sustainable energy future for all. We serve customers in the utility, industry and infrastructure sectors with innovative solutions and services across the value chain. Together with customers and partners, we pioneer technologies and enable the digital transformation required to accelerate the energy transition towards a carbon-neutral future. We are advancing the world’s energy system to become more sustainable, flexible and secure whilst balancing social, environmental and economic value. Hitachi Energy has a proven track record and unparalleled installed base in more than 140 countries. Headquartered in Switzerland, we employ around 40,000 people in 90 countries and generate business volumes of over $10 billion USD.
https://www.hitachienergy.com
https://www.linkedin.com/company/hitachienergy
https://twitter.com/HitachiEnergy

About Hitachi, Ltd.

Hitachi drives Social Innovation Business, creating a sustainable society through the use of data and technology. We solve customers’ and society’s challenges with Lumada solutions leveraging IT, OT (Operational Technology) and products. Hitachi operates under the business structure of “Digital Systems & Services” – supporting our customers’ digital transformation; “Green Energy & Mobility” – contributing to a decarbonized society through energy and railway systems, and “Connective Industries” – connecting products through digital technology to provide solutions in various industries. Driven by Digital, Green, and Innovation, we aim for growth through co-creation with our customers. The company’s consolidated revenues for fiscal year 2022 (ended March 31, 2023) totaled 10,881.1 billion yen, with 696 consolidated subsidiaries and approximately 320,000 employees worldwide. For more information on Hitachi, please visit the company’s website at https://www.hitachi.com.

Attachments

Jocelyn Chang
Hitachi Energy
jocelyn.chang@hitachienergy.com

GlobeNewswire Distribution ID 8881044

Presidential Imbizo goes to the Eastern Cape

President Cyril Ramaphosa will next month host the ninth District Development Model (DDM) Presidential Imbizo at the Magwala Sports Field in the Chris Hani District Municipality in the Eastern Cape.

The imbizo will be held on Friday, 11 August.

The imbizo is a platform for face-to-face engagement between citizens and senior government leaders, to hold the administration to account. It allows government to consult and brief communities on development and service delivery in various areas.

The DDM was approved by government structures, including Cabinet, to integrate service delivery that will be more practical, achievable, implementable, measurable and clearly aligned to the key priorities of the government.

The model seeks to change the face of rural and urban landscapes by ensuring complementarity between urban and rural development, with a deliberate emphasis on local economic development.

The Cabinet-approved District Development Model is due for implementation in all of South Africa’s 44 municipal districts and eight metropolitans.

Preceding the imbizo will be a series of build-up outreach activities led by Ministers, MECs and Mayors in parts of the Chris Hani District Municipality and across the Eastern Cape Province.

The model also seeks to ensure that municipalities are adequately supported and resourced to carry out their mandate.

Source: South African Government News Agency

SARS wins critical court battle against business

The South African Revenue Service (SARS) has welcomed a decision of the Supreme Court of Appeal to dismiss two appeals by a company seeking to validate its business rescue procedures.

The company, PFC Properties and its trust, the De Robillard Family Trust, owed SARS at least R148 million and failed to pay the amount and instead went into business rescue and sold its assets for far below market value.

The assets included a R45 million yacht which was sold for R12 million, another yacht valued at R13 million sold for R570 000 and R50 million value house sold for R11.3 million.

The revenue collector’s commissioner, Edward Kieswetter, condemned the use of business rescue processes in an attempt to avoid paying taxes.

“It was unfortunate that some taxpayers abuse the business rescue proceedings, to the detriment of creditors. In most instances, the fiscus is the main victim.

“SARS will continue to act firmly and decisively when business rescue proceedings are abused to the detriment of the fiscus. We will without any equivocation oppose such abusive applications,” Kieswetter said.

SARS explained the reasons why the court dismissed the applications.

“The issue before the SCA was whether the conduct on the part of PFC and the De Robillard Family Trust’s trustees in launching the business rescue application, constituted an abuse of court process. The SCA held that that application should not have been considered by reason of its use in a scheme of abuse. The Court held that the business rescue application was a stratagem.

“Consequently, the business rescue application could not suspend the liquidation application because the former was tainted by abuse. Apart from this, the De Robillard Family Trust’s trustees failed to make out a case that there was any prospect of rescuing PFC. All its assets had been sold-off and it had lost its substratum. The SCA further held that the liquidation order granted by the Pretoria High Court was unassailable. For these reasons, both appeals were dismissed with costs,” SARS said.

The revenue collector vowed to clamp down on any attempts to avoid paying what is due to the taxman.

“SARS will not stand idle when taxpayers abuse the mechanisms of the Companies Act by acting malignantly to deprive SARS what is due and payable to the fiscus. Any elaborate and carefully calibrated plans to withhold taxes will be resisted emphatically.

“SARS will always work in the manner that supports the growth of the economy with concomitant job creation. Where, for whatever reason businesses do not perform optimally and they are unviable, every role player in the process is duty bound to act professionally and without fear, favour or prejudice against any creditors,” the revenue service said.

Source: South African Government News Agency

Eskom warns against job scam

Eskom has warned members of the public not to fall for job scams purportedly related to vacancies at its power stations, with the latest scam targeting the Medupi Power Station.

According to the power utility, scammers lure unsuspecting victims to interviews in Gauteng and are asked to pay for accommodation and other fees.

“As part of the modus operandi, job seekers are advised to bring money for expenses, such as accommodation and transport, to Lephalale where Medupi Power Station is located. In some instances, the unsuspecting job seekers are required to deposit more money into a bank account for other expenses such as personal protective equipment (PPE) or medical assessment following the interviews, among other reasons.

“Eskom advises job seekers to be aware that vacancies in the organisation are on its recruitment website which can be accessed by visiting www.eskom.co.za and cautions job seekers against using any other links found on the internet. Under no circumstances will Eskom require any payment from applicants during its recruitment process,” the power utility said.

Eskom said that, together with law enforcement, it has instituted an investigation with arrests subsequently made.

“Upon receiving several complaints from members of the public about the recruitment scam at Medupi, Eskom launched a joint operation with the South African Police Service (SAPS), which led to the arrest of three suspects — two females and a male accomplice.

“The suspects were charged at the Douglasdale Police Station on 26 June 2023 and appeared at the Randburg Magistrates’ Court on 28 June 2023. They will appear again at the same court on 16 August 2023,” Eskom said.

Members of the public who may have fallen victim to the scam are encouraged to contact Colonel Naidoo on 082 820 6174 or SAPS on 08600 10111 or SMS the Eskom Crime Line on 32211.

Source: South African Government News Agency

Mpumalanga police condemn brutal killing of girl (5)

The Provincial Commissioner of the South African Police Service in Mpumalanga, Lieutenant-General Semakaleng Daphney Manamela, has strongly condemned the brutal murder of a five year-old girl, allegedly by her cousin.

On Tuesday afternoon, police and paramedics received information about the body of a child found in the bushes.

Upon arrival at the scene, they found the lifeless body of the little girl with her throat slit, as well as stab wounds on her upper body.

She was certified dead by the medical personnel on the scene and police have opened a murder case.

Preliminary investigations indicated that the girl left home with her male cousin to a nearby tuck shop to buy some snacks.

However, the cousin returned alone without the little girl, saying that she had gone to play with other children in the neighbourhood.

However, the family was concerned that something could have happened to the child and they began searching for her until they made the gruesome discovery of her body in the nearby bushes. They immediately alerted the authorities.

Police in Bushbuckridge arrested the suspect on the same day and charged him with murder.

The suspect is expected to appear in the Bushbuckrigde Magistrates’ Court soon. Investigations are ongoing. It is not yet clear if the girl was raped or not, and that will form part of the probe.

Manamela urged parents and guardians to be vigilant with their children.

“It is disheartening and disappointing to learn that some family members are found to be the ones allegedly perpetrating crimes against children, whereas they have been entrusted to safeguard them,” she said.

Source: South African Government News Agency