Sabin Vaccine Institute Begins Phase 2 Clinical Trial for Marburg Vaccine in Uganda

Clinical Trial Preparation
Staff at Makerere University Walter Reed Project preparing for Sabin’s Phase 2 Marburg vaccine clinical trial.

Staff at Makerere University Walter Reed Project preparing for Sabin’s Phase 2 Marburg vaccine clinical trial.

WASHINGTON, Oct. 19, 2023 (GLOBE NEWSWIRE) — The Sabin Vaccine Institute has launched a Phase 2 clinical trial for its vaccine candidate against the lethal Marburg virus. Healthy volunteers received the single-dose vaccine at Makerere University Walter Reed Project (MUWRP) in Kampala, Uganda today.

There are currently no vaccines or antiviral treatments approved to treat Marburg virus disease. Marburg is a filovirus, in the same family as the virus that causes Ebola. Like Ebola, Marburg virus disease spreads between people via direct contact with the blood or other bodily fluids of infected people, is highly virulent, and causes hemorrhagic fever. The disease has a fatality rate of up to 88%.

Based on the ChAd3 platform, Sabin’s single-dose investigational Marburg vaccine was found to be promising in Phase 1 clinical and non-clinical studies, with results showing it to be safe, while eliciting rapid and robust immune responses.

Dr. Betty Mwesigwa, deputy executive director of MUWRP, is the principal investigator for the Kampala portion of the Sabin-sponsored trial. Participants will also be enrolled a few weeks later at a second site at the Kenya Medical Research Institute in Siaya, Kenya, with Dr. Videlis Nduba as principal investigator. In all, 125 volunteers will participate in the trial.

“We have an extraordinary opportunity here to improve our preparedness to save lives and protect people from a deadly and unforgiving disease that typically strikes under-resourced countries first and most,” says Amy Finan, Sabin’s Chief Executive Officer. “Sabin’s Phase 2 clinical trial builds on a solid safety and immunogenicity foundation and we are hoping it will generate the information needed to move the vaccine toward licensure.”

The number of Marburg outbreaks in Africa has climbed steadily in recent years. Two outbreaks of Marburg virus disease have occurred already this year: Equatorial Guinea reported its first ever documented Marburg outbreak, which killed 12 people, followed by Tanzania, where six people succumbed to the virus. Communities in Uganda and Kenya are familiar with Marburg virus disease, having been ravaged by outbreaks over multiple years in the last few decades.

“Makerere University Walter Reed Project (MUWRP) is delighted to partner with the Sabin Vaccine Institute to launch the clinical testing for a preventive Marburg vaccine,” says Dr. Mwesigwa. “Most Marburg virus disease outbreaks have originated in Africa. Uganda alone has registered 4 outbreaks of the disease. We urgently need a vaccine against Marburg because of its potential to cause epidemics with significant death rates. It is imperative for us to test candidate vaccines in Uganda, a country prone to these outbreaks. This work will contribute new knowledge to inform the scientific discovery for an effective vaccine against the deadly Marburg virus.”

The Phase 2 clinical trial for Sabin’s Marburg vaccine will continue to evaluate safety and immunogenicity for the vaccine, this time among a larger group of individuals. This is a randomized, placebo-controlled, double-blind study, meaning that neither the participants nor the researchers will know whether trial participants receive a vaccine dose or a placebo dose until after the trial is over, an approach used to help reduce experimental bias.

Participants in the clinical trial will be monitored for a full year and will include both younger (18-50 years) and older age groups (51-70 years). Interim results are expected next year. In addition to the current trial in Uganda and Kenya, Sabin plans to conduct a similar Phase 2 clinical trial for Marburg in the U.S.

The Marburg vaccine trials are supported by the Biomedical Advanced Research and Development Authority (BARDA), part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, under multi-year contracts between the organizations, including most recently a $36.4 million award for vaccine development and production.

Similarly, BARDA has invested in Sabin for advancing ChAd3 Sudan ebolavirus vaccine candidate, including awarding $28 million this August for Phase 2 clinical trials in the U.S.

To date, Sabin has received around $215 million in contract awards from BARDA for furthering vaccine research and development against Sudan ebolavirus and Marburg virus diseases.

BARDA and Sabin began working together in September 2019 to develop the two monovalent vaccine candidates. Sabin’s Sudan ebolavirus vaccine candidate was the first to arrive in Uganda last year during the disease outbreak that left 55 people dead. Sabin has also initiated plans for a Phase 2 Sudan ebolavirus vaccine clinical trial in Uganda and Kenya.

This project has been supported in whole or in part with federal funds from the Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority (BARDA), under contract numbers 75A50119C00055 and 75A50123C00010.

About the Sabin Vaccine Institute

The Sabin Vaccine Institute is a leading advocate for expanding vaccine access and uptake globally, advancing vaccine research and development, and amplifying vaccine knowledge and innovation. Unlocking the potential of vaccines through partnership, Sabin has built a robust ecosystem of funders, innovators, implementers, practitioners, policy makers and public stakeholders to advance its vision of a future free from preventable diseases. As a non-profit with three decades of experience, Sabin is committed to finding solutions that last and extending the full benefits of vaccines to all people, regardless of who they are or where they live. At Sabin, we believe in the power of vaccines to change the world. For more information, visit www.sabin.org and follow us on X, @SabinVaccine.About Sabin’s Vaccine R&D Using the ChAd3 Platform.

About Sabin’s Vaccine R&D Using the ChAd3 Platform

In August 2019, Sabin announced exclusive agreements with GSK for Sabin to advance the development of the prophylactic candidate vaccines against the deadly Ebola Zaire, Ebola Sudan and Marburg virus. The three candidate vaccines were initially developed collaboratively by the U.S. National Institutes of Health and Okairos, which was acquired by GSK in 2013. The candidate vaccines, based on GSK’s proprietary ChAd3 platform, were further developed by GSK, including the Phase II development for the Ebola Zaire vaccine. Under the agreements between GSK and Sabin, Sabin exclusively licensed the technology for all three candidate vaccines and acquired certain patent rights specific to these vaccines.

About the Makerere University Walter Reed Project

MUWRP is a non-profit biomedical research organization with a mission to mitigate disease threats through quality research, health care and disease surveillance. The project’s scope includes among others; clinical research in infectious and non-infectious diseases such as HIV, Ebola, Marburg, COVID-19, Influenza and Influenza-like illnesses, and neglected tropical diseases such as Schistosomiasis, among others. A major part of the clinical research are clinical trials, where the MUWRP has conducted more than 12 phase I and II vaccine clinical trials including the first Ebola vaccine trial in Africa.

Media Contact:
Monika Guttman
Media Relations Specialist
Sabin Vaccine Institute
+1 (202) 662-1841
[email protected]

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Steel decarbonisation to redefine supply chains by 2050

Wood Mackenzie report says new metallic hubs will emerge as steel industry accelerates carbon abatement efforts

LONDON and HOUSTON and SINGAPORE, Oct. 19, 2023 (GLOBE NEWSWIRE) — According to the latest Horizons report from Wood Mackenzie, the steel industry is set to undergo a significant transformation as decarbonisation efforts accelerate. Titled Metalmorphosis: how decarbonisation is transforming the iron and steel industry the report highlights the emergence of new metallic hubs and the reshaping of steel production and global trade patterns.

Wood Mackenzie’s latest report says electric-arc furnace (EAF) technology, increased use of green feedstock, and evolving carbon policies will play a crucial role in this transformation. Low-carbon intensive EAF production accounts for 28% of global steel output, projected to rise to 50% by 2050. An investment of US$130 billion will be required to achieve this goal.

The shift towards less carbon-intensive steel will drive the demand for greener feedstocks such as DRI (Direct Reduced Iron) and high-grade scrap. Wood Mackenzie predicts that the share of these feedstocks in total metals demand will increase from 36% to 54% by 2050, leading to new production, processing, and trading hubs for low-carbon iron and scrap.

DRI production and trade rise will create investment and revenue generation opportunities across the value chain. Wood Mackenzie forecasts a doubling DRI capacity within 30 years, requiring an estimated US$80 billion investment. This projection does not include potential investments in green hydrogen, smelters for low-grade DRI, pellet hubs, and shipping.

Wood Mackenzie indicates that the location of new green Direct Reduced Iron (DRI) centres will be determined based on their proximity to low-carbon hydrogen production. This is particularly important given the uncertainties surrounding the transportation and storage of traded hydrogen. The Middle East and Australia are well-positioned to take advantage of this opportunity, and the number of projects in these regions is increasing.

Quality will take precedence over quantity as the cost of lower-carbon steel rises. In markets with high carbon prices, importing green DRI to manufacture low-carbon steel using EAFs will become more favourable than importing finished steel from emissions-intensive producers like China and India.

Decarbonising the iron and steel industry, which currently accounts for approximately 8% of global carbon emissions, is a challenging but achievable goal. With the right levels of investment and policy support, this transformation has the potential to redefine trade patterns and the value chain.

Editor’s notes:
Read more information here. To request the report and arrange an interview with the authors, please contact Wood Mackenzie’s media relations team.

About Wood Mackenzie
Wood Mackenzie is the global insight business for renewables, energy and natural resources. Driven by data. Powered by people. In the middle of an energy revolution, businesses and governments need reliable and actionable insight to lead the transition to a sustainable future. That’s why we cover the entire supply chain with unparalleled breadth and depth, backed by over 50 years’ experience in natural resources.

Contacts:
Hla Myat Mon
PR Manager – APAC
[email protected]

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L’édition 2023 de la Semaine du Climat de la région Moyen-Orient/Afrique du Nord ou la mise en lumière du rôle capital du Forum sur les Minéraux du Futur dans la création de chaînes de valeur minières responsables pour une transition énergétique saine

RIYAD, Arabie Saoudite, 18 oct. 2023 (GLOBE NEWSWIRE) — La Semaine 2023 du Climat de la région MOAN organisée à Riyad a mis en évidence le rôle déterminant du Forum sur les Minéraux du Futur (ci-après « FMF ») dans la conception de solutions d’avenir dédiées au monde minéral.

Animé par Aldo Pennini, directeur de la stratégie, des programmes et du contenu du FMF, le panel rassemblait d’éminents experts, parmi lesquels Son Excellence Abdulrahman Al Belushi, sous-ministre adjoint chargé du développement minier au ministère de l’industrie et des ressources minérales, Monsieur l’ingénieur Saud Al-Mandil, vice-président du département technologie et R&D chez Ma’aden, le Docteur Thamer Aldaajani, directeur général de la recherche minière et des hydrocarbures à la Cité du roi Abdulaziz pour la science et la technologie ; Ali Al-Mutairi, directeur exécutif du FMF, le Docteur Abdullah Al-Nabhan, directeur principal de l’enquête et de l’exploration à la Commission géologique saoudienne, et le Professeur Jim Skie, président du Groupe d’experts intergouvernemental sur l’évolution du climat (GIEC).

« Les minéraux représentent une source essentielle à de nombreuses industries et projets », a déclaré Son Excellence Abdulrahman Al Belushi, en soulignant particulièrement la nécessité d’adopter des politiques durables permettant de minimiser l’impact environnemental au bénéfice de la communauté.

Saud Al Mandil a pointé l’engagement de Ma’aden en faveur de la durabilité dans le secteur minier. Ma’aden se donne pour vocation de réduire l’impact environnemental par une gestion responsable des ressources naturelles, conformément à l’engagement du Royaume envers l’Accord de Paris sur le climat.

Thamer Aldaajani a mis en relief le rôle central de la recherche dans la compréhension de l’impact économique et environnemental sur les ressources minérales, et dans l’amélioration de leurs chaînes de valeur. Il a reconnu les enjeux du secteur minier face à la difficulté d’équilibrage entre extraction des minéraux et préservation de l’environnement.

Ali Al-Mutairi a résumé la mission du FMF en déclarant : « Le FMF vise à façonner l’avenir des minéraux dans un contexte de transition énergétique en ouvrant la voie au dialogue et à la collaboration multipartites. Le Forum sert de plateforme internationale et permet aux acteurs du secteur minier d’explorer de nouvelles terres d’opportunités dans une super région minière qui s’étend de l’Afrique à l’Asie occidentale et centrale ».

Abdullah Al-Nabhan a développé la formation géologique du bouclier arabo-nubien, en soulignant l’importance de ses riches ressources minérales vertes dans la transition énergétique. En parallèle, le Professeur Jim Skea a annoncé la toute première intégration du rôle des minéraux dans la transition énergétique dans le prochain rapport pluriannuel du GIEC.

La troisième édition du FMF, sous mécénat du Gardien des deux Saintes Mosquées, Sa Majesté le Roi Salmane ben Abdelaziz d’Arabie saoudite, se tiendra du 9 au 11 janvier 2024 au Centre international de conférences du Roi Abdulaziz de Riyad.

Une photo accompagnant cette annonce est disponible à l’adresse suivante : https://www.globenewswire.com/NewsRoom/AttachmentNg/c7249c16-1580-4825-bd81-b2946880f9f4

Omar Shereen
Tél. : +966 50 663 0489
E-mail : [email protected]

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MENACW 2023 destaca o papel crucial do Future Minerals Forum na formação de cadeias sustentáveis de valor mineral na transição para energias limpas

RIAD, Arábia Saudita, Oct. 18, 2023 (GLOBE NEWSWIRE) — A Middle East and North Africa Climate Week (MENACW) 2023, sediada em Riad, enfatizou o papel crucial do Future Minerals Forum (FMF) na definição do futuro dos minerais.

O painel moderado por Aldo Pennini, Diretor de Estratégia, Programa e Conteúdo do FMF, contou com painelistas notáveis, incluindo Abdulrahman Al Belushi, Vice-Ministro Assistente de Capacitação em Mineração do Ministério da Indústria e Recursos Minerais; Eng. Saud Al Mandil, Vice-Presidente de Tecnologia, P&D e Inovação na Ma’aden; Dr. Thamer Aldaajani, Gerente Geral de Pesquisa em Mineração e Hidrocarbonetos na King Abdulaziz City for Science and Technology; Ali Al-Mutairi, Diretor Executivo do FMF; Dr. Abdullah Al-Nabhan, Diretor Sênior de Pesquisa Geológica e Exploração na Pesquisa Geológica da Arábia Saudita; e Professor Jim Skie, Presidente do Painel Intergovernamental sobre Mudanças Climáticas.

“Os minerais representam um pilar crucial para impulsionar inúmeras indústrias e projetos”, afirmou Abdulrahman Al Belushi. Ele enfatizou a necessidade de operações sustentáveis que minimizem o impacto ambiental e garantam benefícios para a comunidade.

Saud Al Mandil destacou o compromisso da Ma’aden com a sustentabilidade no setor de mineração. A empresa está empenhada em minimizar o impacto ambiental e gerenciar responsavelmente os recursos naturais, alinhando-se ao compromisso do Reino com o Acordo de Paris sobre o clima.

Thamer Aldaajani ressaltou o papel crucial da pesquisa na compreensão do impacto econômico e ambiental dos recursos minerais e no aprimoramento de suas cadeias de valor. Ele reconheceu os desafios enfrentados pelo setor de mineração ao equilibrar a extração de minerais necessários com a preservação ambiental.

Ali Al-Mutairi delineou a missão do FMF, afirmando: “O FMF visa moldar o futuro dos minerais no contexto da transição energética por meio do diálogo e colaboração entre várias partes interessadas. O Fórum serve como uma plataforma internacional, fomentando oportunidades para entidades envolvidas no setor de mineração explorarem possíveis oportunidades na super-região mineral, que se estende da África à Ásia Ocidental e Central”.

Abdullah Al-Nabhan falou sobre as características geológicas do Escudo Árabe, destacando seus abundantes recursos minerais essenciais na transição para energias verdes. Enquanto isso, o professor Jim Skea anunciou que, pela primeira vez, o IPCC incorporará o papel dos minerais na transição energética como parte de seu próximo relatório plurianual.

A terceira edição do FMF, sob o patrocínio do Guardião das Duas Mesquitas Sagradas, Rei Salman bin Abdulaziz, será realizada de 9 a 11 de janeiro de 2024, no King Abdulaziz International Conference Center em Riad.

Uma foto acompanhando este anúncio está disponível em https://www.globenewswire.com/NewsRoom/AttachmentNg/c7249c16-1580-4825-bd81-b2946880f9f4

Omar Shereen
Telefone: +966 50 663 0489
E-mail: [email protected]

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Report claiming 94% contested posts await tribunal incorrect – INEC

The Independent National Electoral Commission (INEC) has described media report that 94 per cent all the elective positions contested in 2023 general elections are being contested at the tribunal as incorrect.

INEC National Commissioner and Chairman, Information and Voter Education Committee, Sam Olumekun, said this in a statement on Thursday in Abuja.

Olumekun said that the attention of the commission had been drawn to a front page report by a newspaper in its Wednesday edition titled: “INEC’s credibility sinks as 94% contested posts await tribunal.”

He said that the commission would have ignored the report if it did not emanate from one of our country’s flagship and reputable newspapers.

He said that, however, the report under reference contained inaccurate figures, mix-up of pre-election and post-election cases.

He added that the report skewed comparative perspective and a headline that suggests that election petitions draw from the action or inaction of INEC.

Olumekun said that basic fact check on the information regularly published by INEC and available on its website would have shown that in 2023, elections were not conducted in 1,280 constituencies, including 782 state assembly seats.

“On the contrary, elections were conducted in 1,491 constituencies across the country made up of 1 Presidential, 28 Governorship, 109 Senatorial, 360 House of Representatives and 993 State Assembly constituencies.

“Similarly, the claim that State Assembly elections were held in only 28 States of the country is made on the lazy assumption that no such elections were held in the eight States of the federation where executive elections are held off-cycle.

“As every attentive Nigerian knows, the tenure of legislators is tied to the legislative houses which is a fixed term of four years from the date the Assembly is inaugurated unlike the term of office of the executive which begins from the date they take the oath of office, “ he said.

Olumekun also faulted the report blaming the pre-election cases arising from the conduct of primary elections by political parties on INEC.

He said those were intra-party cases involving party members in which they joined INEC and seek for reliefs binding on it, even as INEC does not conduct primaries for political parties.

“Thirdly, in pursuit of their right under the law, many litigants in Nigeria unfortunately file election petitions over the most improbable cases and later withdraw them or they are dismissed by the tribunals.

“If the report had taken time to analyse the outcome of the cases decided so far by the tribunals, it would have discovered that out of 1,196 petitions, 712 were dismissed and 179 withdrawn.

“This means that in 891 cases (74.4 per cent), the tribunals found no merit in the petitions and affirmed the result of the elections conducted by INEC.

“It is surprising how the mere filing of petitions constitute a blot on the integrity of the recent elections conducted by INEC when in fact they constitute an integral part of the democratic process, “ Olumekun said.

He added that the said report also analysed the total number of petitions as if they were filed against the outcome of the elections in 94 per cent of all the elective positions without considering details of the cases.

Olumekun said that multiple petitions were filed by candidates and political parties as petitioners in a single constituency.

“For example, in one state in the south south geopolitical zone of the country, eight petitions were filed challenging the governorship election out of which seven were dismissed and one withdrawn.

“Therefore, the number of election petitions filed in respect of all elective offices will certainly outnumber the total number of constituencies/elective offices.

“To spread them across the constituencies and proceed to calculate the percentage is to count some constituencies several times which is methodologically problematic and statistically illogical,” he said.

He added that it was also pertinent to note that the grounds for challenging the outcome of an election as provided in Section 134 of the Electoral Act, 2022 were not limited to the conduct of election by the commission.

Olumekun said that an election might be questioned on the ground that the winner of the election was not qualified to contest the election by virtue of his academic qualifications, age etc.

He said that many of the petitioners did not challenge the conduct of the elections by INEC but the eligibility of candidates or their nomination by political parties.

He added that under the law, INEC has no power to screen candidates, as only the courts can disqualify candidates.

“Six, a comparative analysis would have addressed the deliberate effort in the report to portray the 2023 General Election as regressive on account of litigation without empirical evidence.

“Over the last three electoral cycles, the number of election petitions may be rising but not the number of upturned elections. In 2015, 663 cases were filed at the tribunals, 87 (13.1 per cent) were nullified and the commission ordered to conduct re-run in some polling units or entire constituencies.

“In 2019, 807 petitions were filed but elections were only re-run in 30 (3.71per cent) consituencies (three Senatorial Districts, 13 Federal Constituencies and 14 State Constituencies).

“While the 2023 post-election litigations are ongoing, all five petitions filed in respect of the Presidential election were dismissed while three are pending on appeal,” he said

Olumekun said that as at Monday Oct 16, out of 82 governorship election petitions, 72 (87.8 per cent) were either dismissed or withdrawn by the petitioners.

“For senatorial elections, 146 petitions were filed out of which 100 (68.5per cent) were dismissed or withdrawn.

“For the House of Representatives, 413 petitions were filed out of which 309 (74.81 per cent) were dismissed or withdrawn while for State Houses of Assembly, 550 petitions were filed out of which 468 (82.4 per cent) were dismissed or withdrawn,” he said.

Olumekun said it was inappropriate to solely assess the credibility of INEC or the conduct of the 2023 General Election on the number of petitions filed by litigants who, in any case, have the right to do so under the law.

“While we wish to restate our continuing partnership with the media, it is prudent to state that the pen should be used to strengthen rather than impugn the integrity of public institutions particularly where basic statistics demand that we should be circumspect, “ he said. (NAN)(www.nannews.ng)

Source: News Agency of Nigeria

NDE trains 100 youths on sustainable agriculture in Imo

The National Directorate of Employment (NDE) has commenced the training of 100 youths on sustainable agricultural development skills in Imo.

Director-General of the NDE, Mallam Abubakar Nuhu-Fikpo flagged off the training in Owerri, on Thursday.

Represented by NDE’s Director of Planning, Research and Statistics, Mr Edmund Onwuliri, Nuhu-Fikpo said the training was part of the directorate’s Sustainable Agriculture Development Training Scheme (SADTS).

He said the training ,holding in 12 states of the federation, aimed at creating jobs for people in rural communities.

The director-general added that the training with focus on modern innovative technology in agriculture would last for three months.

The DG also said that each trainee would receive the sum of N5,000 per month as transport allowance.

According to him, the 100 beneficiaries would be trained on vegetable farming, snail, poultry and pig farming, with their value chains.

“This training will surely create more jobs for people in rural communities and reduce rural to urban migration.

“The NDE attaches a high premium to the empowerment of people and is therefore fully prepared to work with the state government to achieve this,” he said.

Mrs Chisara Egwim-Chima, NDE Coordinator in Imo, said the time had come for rural dwellers to overcome poverty, unemployment, economic backwardness and hunger through better agricultural practices and improved food production.

She advised the beneficiaries to be punctual and committed to the training so as to justify the resources expended on the scheme.

A representative of the Association of Micro Credit Institutions of Nigeria, Mrs Comfort Nweke, commended the NDE for the initiative.

She promised that micro start-up loans would be made available to the beneficiaries upon completion of the training.

Mr Onyedikachi Chikaodi,Special Adviser to Gov. Hope Uzodinma on Religious Mobilization, restated the state government’s readiness to support NDE to create more jobs and fight unemployment in the state. (NAN) (www.nannews.ng)

Source: News Agency of Nigeria