Overdue for sanity | Daily FT

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Daily Financial Times

“Vaccine” failure is so glaring, it is shocking that there are still people “clinging” to the myth of its efficacy – Pic by Shehan Gunasekara Well, it has been a fascinating 10 days or so for “confessions.” US CDC Director Walensky announced, “The overwhelming number of deaths, over 75%, occurred in people who had at least four comorbidities.” When asked out of the 800k ascribed COVID US deaths, how many actually died “from” COVID as a primary cause of death, she said, staggeringly, “we are gathering data,” or words to that effect. She had no answer ready to hand. If this vague piffle doesn’t … Continue reading “Overdue for sanity | Daily FT”

Taconic Biosciences Adds New Humanized Immune System (HIS) Model to Its Portfolio For Immuno-Oncology Research

New huNOG-EXL EA Model Extends Study Windows Significantly

RENSSELAER, N.Y., Jan. 18, 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces the launch of the huNOG-EXL EA (Early Access) humanized immune system (HIS) mouse. This product expands Taconic’s widely used HIS portfolio. huNOG-EXL EA significantly lengthens the study window during which a myeloid-lineage HIS mouse model can be used successfully.

Taconic’s huNOG-EXL models support human myeloid and lymphoid cells, making these mice especially useful for immuno-oncology research and other immune-related applications. With the longest lifespan of any myeloid-supportive HIS model, the original huNOG-EXL model (now called huNOG-EXL SA, or Standard Access) has been successfully applied in preclinical drug discovery research since 2016. The huNOG-EXL SA model is provided after a quality control step at 10 weeks post-engraftment. Feedback from users suggests research applications requiring particularly long study timelines or importation into regions with long quarantine periods present experimental and logistical hurdles that can limit the utility of the Standard Access (SA) model.

The new huNOG-EXL EA model removes those challenges by providing access to huNOG-EXL mice soon after engraftment, extending the useful study window. This makes the huNOG-EXL EA ideal for engraftment of slow-growing tumors, longer treatment paradigms, or various study customizations. Early access to an extended myeloid lineage model is also advantageous to researchers who face model importation quarantines, which would otherwise consume a significant portion of the useful study window for these mice. Because the huNOG-EXL EA model is shipped before an engraftment QC step is possible, it is made using cells from donors previously validated to engraft well so as to reduce the risk of engraftment failures.

“The huNOG-EXL EA model meets critical scientific needs for investigators performing immuno-oncology research or studying other immune-related diseases,” said Dr. Michael Seiler, vice president of commercial products at Taconic. “After conducting extensive research and development, along with rigorous beta testing with several industry partners, Taconic is excited to now offer the new model and expand the usefulness of this unique humanized mouse.”

To learn more about Taconic’s huNOG-EXL EA model, please contact us at 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email [email protected].

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates three service laboratories and six breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

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Nancy J Sandy

CEO

608-332-6320

[email protected]

New on DVD: Small town turned upside down in ‘American Rust’

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Tribune News Service

A murder mystery set in a fictional Rust Belt town tops the DVD releases for the week of Jan. 25. “American Rust”: Showtime series adapted from the 2009 novel by Philipp Meyer stars Jeff Daniels as the police chief of an economically depressed community in western Pennsylvania who becomes conflicted after his lover’s son is accused of murder. “Comparison with ‘Mare of Easttown’ feels unavoidable, if for no other reason than that show is set in the eastern end of the same state, in a similarly if not so extremely distressed small town, with a generous complement of bad and broken marriages, tro… Continue reading “New on DVD: Small town turned upside down in ‘American Rust’”

OKX overtakes global crypto exchanges as 2nd largest, rebrands as cross-platform services provider

Formerly OKEx, OKX’s new brand highlights the platform’s robust suite of crypto, NFT and DeFi investing products

VICTORIA, Seychelles, Jan. 18, 2022 (GLOBE NEWSWIRE) — OKX, which recently became the second largest cryptocurrency exchange in the world by spot trading volume, today announced a company-wide rebrand that reflects the dynamism and accelerating adoption of cryptocurrency. Founded in 2017 as a cryptocurrency trading service, OKX has since amassed over 20 million users and expanded its suite of digital asset investing products to include OKX Earn, a tool for earning passive crypto income; an NFT marketplace and decentralized application discovery hub; and most recently, MetaX, OKX’s new decentralized mode that features a cross-chain dashboard and self-custody Web 3.0 wallet for storing digital assets, including NFTs.

This shift, as highlighted by the company’s name change from OKEx to OKX, reflects the platform’s growing number of wealth creation opportunities beyond the exchange, which investors use to trade hundreds of digital assets on spot, margin and derivatives markets.

As part of the move, OKX has declared its mission to be “to remove barriers to wealth creation by giving you access to everything our decentralized future holds.” This underscores the platform’s ongoing evolution towards decentralization, which includes giving investors the option to self-custody their digital assets. Distinct from other centralized cryptocurrency exchanges, OKX is committed to gradually decreasing the company’s level of involvement in user activity, with the ultimate goal of shedding intermediation entirely.

“OKX is moving beyond the standard centralized exchange model to give our customers an end-to-end cryptocurrency experience,” said Jay Hao, CEO of OKX. “Most importantly, we’re doing this while upholding the core principles of crypto — decentralization and autonomy. Our goal is to give customers the tools they need to easily and securely earn, transfer, and spend their wealth as they see fit, without intermediation from us. We’ve dropped the ‘E’ from our name because we’re so much more than an exchange, just like crypto is so much more than a speculative asset.”

OKX, which lists over 250 digital assets and has long held the #1 rank for cryptocurrency futures trading volumes, recently became the second largest cryptocurrency spot trading platform in the world. In 2021, total trading volume on the platform, including spot and derivatives instruments, grew over 700%, while the number of trades executed on the platform increased over 480%. Staking, savings and DeFi offerings via OKX Earn saw over $5.1 billion deposited by users, and paid out over $314 million in passive income this past year.

To learn more, please visit OKX.com and follow @OKX on Twitter.

About OKX

Founded in 2017, OKX is a world leading cryptocurrency exchange and ecosystem. OKX has innovatively adopted blockchain technology to reshape the financial ecosystem and offers some of the most diverse and sophisticated products, solutions and trading tools on the market. Trusted by more than 20 million people in 180 regions across the globe, OKX’s mission is to remove barriers to wealth creation by offering access to everything the decentralized future holds. With its unwavering commitment to innovation, OKX envisions a world of financial inclusion for all through the power of crypto and decentralized finance.

Contact us

Email: [email protected]
Olivia Capozzalo:
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Good news for kung fu enthusiasts around the world – Shaolin Temple launches kung fu online games

DENGFENG, China, Jan. 18, 2022 /PRNewswire/ — With the Chinese New Year around the corner, China’s Songshan Shaolin Temple and Shaolin Culture Centers across the world have launched a global kung fu contest – “Happy Chinese New Year: Shaolin Kung Fu Online Games.”

“Shaolin kung fu boasts the value of fitness, enlightenment, and harmony,” said the abbot of the Shaolin Temple, Master Shi Yongxin. “As countries around the world battle the COVID-19 pandemic, the Shaolin Temple launched the competition online with the aspiration of promoting peace, friendship, and health, hoping that kung fu fans around the globe gain health, fitness, and happiness,” the abbot added.

The Shaolin Temple organizes year-end kung fu examinations for the monks at the end of each year to encourage kung fu monks to be more brave and diligent.

This year, the examination will be launched online for kung fu lovers of all ages across the globe. Participants will only need to upload a video to the official website of the activity.

The online kung fu games promote communication and interaction between people around the globe against the backdrop of epidemic curbing. The online games are not only an arena for global competitors but also a joyous “family reunion” of all kung fu enthusiasts.

The Chinese zodiac sign of 2022 is the Tiger, and the tiger represents justice, majesty, bravery, and diligence in Chinese culture, which identifies with the concept of Shaolin kung fu.

Shaolin Kung fu has a long history of more than 1,500 years and is one of China’s top-level martial art schools with a complete system. As a national intangible cultural heritage of China, Shaolin kung fu illustrates the desire for supernatural powers and the pursuit of extraordinary wisdom.

The Shaolin Temple has established Shaolin Culture Centers in more than 120 cities on five continents, with more than tens of millions of disciples. Former South African President Nelson Mandela praised Shaolin culture for the human values it instills. Moreover, Stephen Orlins, president of the National Committee on United States-China Relations recalled the legacy of the “ping-pong diplomacy” when talking about Shaolin kung fu, after watching a kung fu performance at the United Nations headquarters.

Registration for the games is now open until January 20 at 24:00, local time. Please visit the official website and App of the Shaolin Temple for more details.

Photo – https://mma.prnewswire.com/media/1728275/image_1.jpg

Class of 2021 went through two years of disruption due to COVID-19

The Class of 2021 was the first Grade 12 cohort to experience the harsh realities of the pandemic for two consecutive years, Umalusi said on Tuesday.

Addressing a media briefing, Umalusi CEO, Dr Mafu Rakometsi, said that consequently this class needed more academic support compared to their predecessors.

The matric Class of 2021 was the eighth Grade 12 cohort to write final examinations under the Curriculum Assessment Policy Statements (CAPS).

Rakometsi said that the most important beneficiary of Umalusi’s quality assurance work are the learners – who are eager to know whether Umalusi has done its job to ensure the credibility of their hard earned qualifications.

“The Class of 2021 was subjected to the realities of the COVID-19 pandemic for two consecutive years, which included a hybrid mode of teaching and learning such as online and rotational classes,” Rakometsi said.

He said that despite the adverse effects of the COVID-19 pandemic, which continued to be a significant factor during the 2021 academic year, Umalusi is entrusted with a critical task of assuring the quality of the entire value chain of the national examination process.

“Regardless of the challenges presented by COVID-19, Umalusi’s quality assurance process focused on the following aspects of its mandate: the external moderation of question papers for all subjects/learning areas/instructional offerings across all qualifications and assessment bodies, verification of a sample of site-based assessment (SBA) marks, monitoring of the assessment bodies’ state of readiness to conduct and manage the 2021 national examinations, monitoring the conduct of examinations, monitoring and verification of marking as well as the standardisation and approval of results,” he said.

The CEO said that Umalusi has taken note of the evidence-based reports on interventions and improvement strategies implemented by all assessment bodies, including the Department of Basic Education and the positive impact of these on the overall assessment system as well as on teaching and learning.

In terms of the quality of question papers, Rakometsi said that this is an essential aspect of the integrity and credibility of the examination.

“Therefore, it is pleasing to see a marked improvement in the overall quality of question papers submitted by assessment bodies as more papers are approved after the first or second submission to external moderators,” he said.

Touching on irregularities, Rakometsi cautioned learners against joining study WhatsApp groups where papers are shared.

“If a paper is shared, all group members will be implicated, including those who did not intend to cheat,” he said.

Umalusi further commended all assessment bodies for doing their best to comply with COVID-19 regulations in the administration, conduct and management of the 2021 NSC examinations.

Source: South African Government News Agency